Fragmentation of protonated peptide ions via interaction with metastable atoms |
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Authors: | Berkout Vadym D |
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Affiliation: | MassTech, Inc., Columbia, Maryland 21046, USA. vberkout@apmaldi.com |
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Abstract: | Fragmentation of protonated peptide ions via interaction with low kinetic energy electronicallyexcited metastable argon atoms was studied in a linear trap-time-of-flight mass spectrometer. Metastable argon atoms were generated using a glow discharge-type source. Protonated peptide ions of substance P, bradykinin, fibrinopetide A, and insulin oxidized chain B were produced by electrospray ionization and trapped in a quadrupole ion guide for 100-400 ms. Intensive series of c- and z-ions were observed in all cases. The kinetic measurements of the fragmentation rates are consistent with calculations of the reaction cross section based on the Landau-Zener approximation. |
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