Use of hematopoietic cytokines to accelerate the recovery of the immune system in irradiated mice |
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Authors: | D Frasca F Guidi M Arbitrio C Pioli G Leter M Spano G Doria |
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Affiliation: | Laboratory of Immunology, AMB-PRO-TOSS, ENEA CR Casaccia, Rome, Italy. |
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Abstract: | In our previous studies aimed at designing appropriate strategies to accelerate recovery of the immune system after irradiation, we found that the hematopoietic cytokine recombinant murine (rmu) interleukin (IL)-3 was able to induce differentiation and growth of thymocytes and splenic T and B lymphocytes in mice exposed to x-rays (200-500 cGy). The recovery, however, was complete at 7 days only after a dose of 200 cGy, whereas 2, 3, and 4 weeks were necessary to achieve full recovery after 300, 400, and 500 cGy, respectively. These studies were extended to investigate the effects of another hematopoietic cytokine, recombinant human (rhu) IL-11, a bone marrow stromal-derived cytokine, administered together with IL-3 to irradiated mice. The synergistic effect of the two cytokines was evident when relatively small doses of rhu IL-11 were injected with an optimal dose of rmu IL-3. |
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