Partial Crystallization Behavior during Spray Drying: Simulations and Experiments

Simulations of crystallization behavior in a spray dryer have been performed using modifications to a model developed by previous workers and applied to a Buchi-290 laboratory-scale dryer. The potential crystallization behavior has been modeled using Williams-Landel-Ferry kinetics. Explorations using the model have suggested that the air inlet temperature is an important variable affecting crystallization in the dryer. The explorations suggested drying conditions that permitted reasonable drying while controlling the degree of crystallization. These conditions were examined and tested experimentally, also showing that the apparent degree of crystallinity was affected by the inlet air temperature over the range of inlet temperatures from 134°C (∼55% crystalline) to 210°C (∼76% crystalline). The simulation also predicted the trends in the experimental results from previous workers where their experimental results are considered in terms of the measurement techniques used in each case, suggesting that the simulation is a reasonable tool for developing operating conditions for drying equipment to give low or high degrees of crystallinity in the products.