生物高分子材料血液相容性研究

生物高分子材料广泛应用于临床医疗,可用作人工血管、起搏器、组织工程支架等,因而必须具备良好的血液相容性.综述了生物高分子材料血液相容性的研究现状,主要包括凝血、血栓形成机理以及抗凝血系统等,重点介绍了高分子材料植入体内引起凝血及血栓形成的具体机制,阐述了设计微相分离结构、化合物接枝改性、引入生物活性分子、材料表面内皮化等改善材料血液相容性的主要途径.最后从分子生物学角度出发展望了今后高分子材料改性的研究方向.

Study on Blood Compatibility of Biopolymer Material

Biopolymer materials are widely used in clinical treatment,which can be used as artificial blood vessel,pacemaker,scaffolds for tissue engineering,etc.Thus good haemocompatibility is required.The research status of haemocompatibility of biopolymer materials is reviewed,such as the mechanisms of clotting and thrombosis,anti-coagulant system;then the mechanisms of clotting and thrombosis induced by leading in biopolymer materials are introduced,and the major pathways of modification used to enhance the haemoc...