| 对乙酰氨基酚处方前研究 |
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| 引用本文： | 解雪乔. 对乙酰氨基酚处方前研究[J]. 广州化工, 2014, 0(10): 130-133 |
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| 作者姓名： | 解雪乔 |
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| 作者单位： | 健雄职业技术学院生物与化学工程系,江苏太仓215411 |
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| 摘 要： | 对对乙酰氨基酚进行处方前研究,为设计优良的处方奠定基础。研究表明,对乙酰氨基酚的熔点为168.93℃,在30~270℃间其失重为98.66%,其结构为不规则的块状结晶,而且吸湿性很小,且其溶液和固态稳定性良好。采用HPLC分析对乙酰氨基酚在浓度3.0~200.0μg/mL范围内线性关系良好(R2=0.9999)。样品的回收率为99.33%~101.33%,其RSD小于0.96%,该方法测定对乙酰氨基酚的检测限为1.103 5μg/mL。本文为建立体外分析方法,以及进一步的处方研究工作打下基础。
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| 关 键 词： | 对乙酰氨基酚 处方前研究 高效液相色谱法 |
Pre-formulation Study on Acetaminophen |
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| Affiliation: | XIE Xue - qiao (Department of Biochemical Engineering, Chien -shiung Institute of Technology, Jiangsu Taicang 215411, China) |
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| Abstract: | The pre - formulation of acetaminophen was studied in order to design the good prescription. Research showed that the acetaminophen melting point was 168.93 ℃. In 30 - 270℃, its weightlessness was 98.66%. Its structure for irregular massive crystallization, and hygroscopic was small. Based on HPLC method, the linear range of acetaminophen were 3.0 -200.0 μg/mL（R2 =0. 9999）, the recovery was 99.33% - 101.33% （RSD 〈0.96% ）, and the detection limit was 1. 103 5μg/mL. It laid the foundation to set up for in vitro analysis method and further research work. |
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| Keywords: | acetaminophen pre - formulation HPLC |
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