Nanoengineering the heart: conductive scaffolds enhance connexin 43 expression |
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Authors: | You Jin-Oh Rafat Marjan Ye George J C Auguste Debra T |
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Affiliation: | School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States. |
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Abstract: | Scaffolds that couple electrical and elastic properties may be valuable for cardiac cell function. However, existing conductive materials do not mimic physiological properties. We prepared and characterized a tunable, hybrid hydrogel scaffold based on Au nanoparticles homogeneously synthesized throughout a polymer templated gel. Conductive gels had Young's moduli more similar to myocardium relative to polyaniline and polypyrrole, by 1-4 orders of magnitude. Neonatal rat cardiomyocytes exhibited increased expression of connexin 43 on hybrid scaffolds relative to HEMA with or without electrical stimulation. |
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