| 新型药物载体聚乙烯-聚丙交酯载药颗粒的制备及表征 |
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| 引用本文： | 姜维,王运东,张建铮,甘泉,张汉威,贝建中,赵秀文,费维扬.新型药物载体聚乙烯-聚丙交酯载药颗粒的制备及表征[J].化工学报,2006,57(2):461-464. |
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| 作者姓名： | 姜维 王运东 张建铮 甘泉 张汉威 贝建中 赵秀文 费维扬 |
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| 作者单位： | 清华大学化工系化学工程联合国家重点实验室 |
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| 摘 要： | Methoxy poly （ethylene glycol） -poly （D, L-lactide） block copolymers （PEG-PLA） were prepared through ring-opening polymerization. The oil in water suspension method was used to prepare block copolymer micelles. The critical micelle concentration （CMC） by fluorescence spectroscopy was 0. 0056 mg· ml^- 1. The physical state of the inner core region of micelles was characterized with ^1 HNMR. The size of indomethacin （IMC） loaded micelles measured by dynamic light scattering （DLS） showed narrow monodisperse size distribution and the average diameters were less than 50 nm. In addition, the nanoparticles with relatively high drug loading content （DLC） were obtained.
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| 关 键 词： | 药物载体 聚乙醇-聚丙交酯 载药颗粒 制备 表征 胶囊 共聚体 |
| 文章编号： | 0438-1157（2006）02-0461-04 |
| 收稿时间： | 2005-09-19 |
| 修稿时间： | 2005-09-19 |
Preparation and characterization of biodegradable nanoparticles from methoxy poly(ethylene glycol)- poly (D,L-lactide)block copolymers as novel drug carriers |
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| JIANG Wei,WANG Yundong,ZHANG Jianzheng,GAN Quan,ZHANG Hanwei,BEI Jianzhong,ZHAO Xiuwen,FEI Weiyang.Preparation and characterization of biodegradable nanoparticles from methoxy poly(ethylene glycol)- poly (D,L-lactide)block copolymers as novel drug carriers[J].Journal of Chemical Industry and Engineering(China),2006,57(2):461-464. |
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| Authors: | JIANG Wei WANG Yundong ZHANG Jianzheng GAN Quan ZHANG Hanwei BEI Jianzhong ZHAO Xiuwen FEI Weiyang |
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| Abstract: | Methoxy poly(ethylene glycol)-poly(D,L-lactide) block copolymers (PEG-PLA) were prepared through ring-opening polymerization.The oil in water suspension method was used to prepare block copolymer micelles. The critical micelle concentration (CMC) by fluorescence spectroscopy was 0.0056 mg·ml-1. The physical state of the inner core region of micelles was characterized with 1HNMR. The size of indomethacin (IMC) loaded micelles measured by dynamic light scattering (DLS) showed narrow monodisperse size distribution and the average diameters were less than 50 nm. In addition, the nanoparticles with relatively high drug loading content (DLC) were obtained. |
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| Keywords: | drug carriers poly(ethylene glycol) poly(D L-lactide) block copolymer micelles |
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