| 吡噻菌胺关键中间体的制备研究进展 |
| |
| 引用本文： | 杨汪松,陈伟,李华,蒋强. 吡噻菌胺关键中间体的制备研究进展[J]. 农药, 2020, 59(4): 253-255,260 |
| |
| 作者姓名： | 杨汪松 陈伟 李华 蒋强 |
| |
| 作者单位： | 浙江省化工研究院有限公司,杭州310023;浙江省化工研究院有限公司,杭州310023;浙江省化工研究院有限公司,杭州310023;浙江省化工研究院有限公司,杭州310023 |
| |
| 摘 要： | 总结了文献报道的吡噻菌胺关键中间体1-甲基-3-三氟甲基-1H-吡唑-4-甲酸的制备工艺路线和合成方法。1-甲基-3-三氟甲基-1H-吡唑-4-甲酸主要由三氟乙酰乙酸乙酯进一步反应得到,主要有6条合成路线,其中三氟乙酰乙酸乙酯路线工艺简单、反应条件温和、原料易得等特点,适合工业化生产。
|
| 关 键 词： | 吡噻菌胺 中间体 三氟乙酰乙酸乙酯 缩合 甲基肼 |
Progress in the Preparation of Key Intermediates of Penthiopyramine |
| |
| YANG Wang-song,CHEN Wei,LI Hua,JIANG Qiang. Progress in the Preparation of Key Intermediates of Penthiopyramine[J]. Pesticides, 2020, 59(4): 253-255,260 |
| |
| Authors: | YANG Wang-song CHEN Wei LI Hua JIANG Qiang |
| |
| Affiliation: | (Zhejiang Research Institute of Chemical Industry,Hangzhou 310023,China) |
| |
| Abstract: | The preparation process and synthesis method of 1-methyl-3-trifluoromethyl-1 H-pyrazole-4-carboxylic acid,a key intermediate of penthiopyramine,were summarized in the literature.1-methyl-3-trifluoromethyl-1 H-pyrazole-4-carboxylic acid is mainly obtained by further reaction of ethyl trifluoroacetoacetate,and there are mainly six synthetic routes,wherein the ethyl trifluoroacetoacetate route is simple.It has the characteristics of mild reaction conditions and easy availability of raw materials,which is suitable for industrial production. |
| |
| Keywords: | pythiabendamide intermediates ethyl trifluoroacetoacetate condensation methylhydrazine |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
