微通道反应器中精细化学品合成危险工艺研究进展

卤化、氧化、重氮化、硝化以及催化加氢是精细化工生产中的重要反应，通常以间歇方式在釜式反应器中进行，存在安全隐患，并且反应效率低。微通道反应器技术的发展为解决上述问题提供了有效途径，因此，发展基于微通道反应器的安全高效合成工艺成为当前精细化工领域的研究热点之一。该文综述了近年来微通道反应器中涉及精细化工产品合成危险工艺的研究进展，并指出了微通道反应器存在的不足和今后研究的方向。

Progresses in fine chemical synthesis in microchannel reactors related to hazardous reactions

Halogenation, oxidation, diazotization, nitration and hydrogenation are important reactions in fine chemical production, which are generally carried out in batch reactors currently, leading to potential safety hazards and low efficiency. The development of microchannel reactor technology provides an effective platform to solve the above problems. Therefore, the investigation on synthetic processes with safety and efficiency in microchannel reactors has become one of the hotspots in the area of fine chemicals. Herein, the research progresses in the synthetic processes of fine chemicals involving hazardous reactions in microchannel reactors in recent years are summarized, from which it can be concluded that fine chemical production could be performed in more safe and efficient protocols in the future. Besides, the current deficiencies of microchannel reactors and the research directions were pointed out.