Cytosine Arabinoside Release from Polymeric Matrices

Cytosine arabinoside (Ara-C) has been used in the treatment of acute myeloid leukemia. However, rapid deamination reduces its effectiveness. Polymeric matrices containing ara-C were prepared in polyether polyurethane copolymer to form a protective, supply of ara-C. Release studies from these devices showed linear relationships between Q, the amount release per unit area, versus the square root of time. Burst effects were predominant at higher loading doses. The diffusivity values indicated that enough drug could pass through the polymer for the combination to have potential application as implants in cancer therapy.