| N,N-二甲基甲酰胺二甲基缩醛制备工艺优化 |
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| 引用本文： | 潘毅,陈蔚,陶勇.N,N-二甲基甲酰胺二甲基缩醛制备工艺优化[J].精细化工中间体,2008,38(5). |
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| 作者姓名： | 潘毅 陈蔚 陶勇 |
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| 作者单位： | 天津药物研究院,天津,300193 |
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| 摘 要： | 改进了N,N-二甲基甲酰胺二甲基缩醛(DMFA)的制备工艺,优化合成条件为:n(甲醇钠)∶n硫酸二甲酯)=1.2∶1、-5~5℃滴加亚胺络合物2,滴加时间2 h,-5~5℃反应2 h。在此条件下,收率由40%~70%提高至76%~80%,产品含量98%。
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| 关 键 词： | N N-二甲基甲酰胺二甲基缩醛 工艺优化 中间体 |
Optimieation on Synthesis Technology of N,N-Dimethylformamide Dimethyl Acetal |
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| PAN Yi,CHEN Wei,TAO Yong.Optimieation on Synthesis Technology of N,N-Dimethylformamide Dimethyl Acetal[J].Fine Chemical Intermediates,2008,38(5). |
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| Authors: | PAN Yi CHEN Wei TAO Yong |
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| Affiliation: | PAN Yi,CHEN Wei,TAO Yong(Tianjin Institute of Pharmaceutical Research(TIPR),Tianjin 300193,China) |
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| Abstract: | The preparative method of N,N-dimethylformamide dimethyl acetal was improved and optimized for its industrialized production.The optimal conditions were obstained as following:the molar ratio of n-sodium methylate and dimethyl sulfate was 1.2∶1,the reaction temperature was-5~5℃,and the reaction time was 4 h.The yield increases from 40%~70% to 76%~80%,and purity of product was 98%. |
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| Keywords: | N N-dimethylformamide dimethyl acetal optimieation on synthesis technology intermediate |
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