|
|||||
|
|
Optimization of Phospholipid Nanoparticle Formulations Using Response Surface Methodology |
|
| Authors: | Sumaira Naeem Lik Voon Kiew Lip Yong Chung Vicit Rizal Eh Suk Asif Mahmood Misni Bin Misran |
| Affiliation: | 1. Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia 2. Department of Pharmacology, Faculty of Medicine Building, University of Malaya, 50603, Kuala Lumpur, Malaysia 3. Department of Pharmacy, Faculty of Medicine Building, University of Malaya, 50603, Kuala Lumpur, Malaysia 4. University of Chinese Academy of Sciences, Beijing, China |
| Abstract: | The present study deals with the optimization of phospholipid liposome formulations to mimic red blood cells. Optimization of different concentrations of distearylphosphatidylcholine, dipalmitoylphosphatidylcholine, and phosphatidylserine at a fixed concentration of lecithin and Tween® 80 was done using response surface methodology. The optimized formulation produced liposomes with a particle size in the range of 112–196 nm. The optimized formulation shows low encapsulation efficiency at low levels of insulin but increases at higher loading levels. Formulated vesicles fulfill the size requirement for intravenous drug delivery. The present system is environmentally friendly with respect to biodegradability and biocompatibility. |
| Keywords: | Optimization Drug carrier size Phospholipids Response surface methodology Average particle size |
| 本文献已被 SpringerLink 等数据库收录！ | |