Antibacterial Activity of Alanine-Derived Gemini Quaternary Ammonium Compounds |
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Authors: | Agata Piecuch Ewa Ob??k Katarzyna Guz-Regner |
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Affiliation: | 1.Institute of Genetics and Microbiology,University of Wroc?aw,Wroc?aw,Poland |
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Abstract: | The antibacterial activity of alanine-derived gemini quaternary ammonium salts (chlorides and bromides) with various spacer and alkyl chain lengths was investigated. The studied compounds exhibited a strong bactericidal effect, especially bromides with 10 and 12 carbon alkyl chains and 3 carbon spacer groups (TMPAL-10 Br and TMPAL-12 Br), with a short contact time. Both salts dislodged biofilms of Pseudomonas aeruginosa and Staphylococcus epidermidis, and were lethal to adherent cells of S. epidermidis. Bromide with 2 carbon spacer groups and 12 carbon alkyl chains (TMEAL-12 Br) effectively reduced microbial adhesion by coating polystyrene and silicone surfaces. The results obtained suggest that, after further studies, gemini QAS might be considered as antimicrobial agents in medicine or industry. |
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Keywords: | Gemini quaternary ammonium compounds Biofilm Adhesion Pseudomonas aeruginosa Staphylococcus epidermidis |
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