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Synthesis of Ecofriendly Functionalized Oxadiazole,Imidazole, Triazole and Pyridine Derivatives
Authors:Refat El-Sayed  Amani Shaldom  Layla Al Mazrouee
Affiliation:1.Chemistry Department, College of Applied Sciences,Umm Al-Qura University,Makkah,Saudi Arabia;2.Chemistry Department, Faculty of Science,Benha University,Benha,Egypt
Abstract:5-Pentadecyl-1,3,4-oxadiazol-2-amine (2) was employed as key intermediate for the synthesis of some new functionalized five and six membered heterocyclic derivatives. The synthesized compounds were reacted with propylene oxide to obtain surface active agents having good surface activity, high solubility in water and good biodegradability. Moreover, the functionalized surfactants showed good antimicrobial activity against gram negative and gram positive organisms. The new compounds are easily synthesized, economical and environmentally friendly and are expected to constitute an important class of organic compounds for medicinal purposes in the future.
Keywords:Synthesis  Heterocyclic derivatives  Antimicrobial and surface activities
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