| 芳香醛和芳香胺参予的Mannich反应及其合成应用 |
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| 引用本文： | 肖敏 村松Y^b. 芳香醛和芳香胺参予的Mannich反应及其合成应用[J]. 化学试剂, 1997, 19(1): 8-11 |
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| 作者姓名： | 肖敏 村松Y^b |
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| 作者单位： | 湖南大学化学化工系!长沙410082，湖南大学化学化工系!长沙410082，国立技科大学工学院，日本丰桥441，湖南大学化学化工系!长沙410082，国立技科大学工学院!日本丰桥441，湖南大学化学化工系!长沙410082，国立技科大学工学院，日本丰桥441 |
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| 基金项目： | 日本政府文部省资助，国家教委与机械部资助 |
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| 摘 要： | 研究了芳香胺和芳香醛参予的Ｍａｎｎｉｃｈ反应及其合成应用，以它们的原料合成了１０余种新的Ｍａｎｎｉｃｈ碱，也使Ｍａｎｎｉｃｈ反应由单一甲醛扩展到芳香醛，产率为６２．３％～９０．４％。
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| 关 键 词： | Mannich反应 Mannich碱 芳香醛 芳香胺 |
On Mannich Reactions with aromatic aldehydes and aromatic amines and their application in organic synthesis |
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| Xiao Min, Wu Xiaoping,Liang Benxi, Muramatsu Y, Li Zhiliang. On Mannich Reactions with aromatic aldehydes and aromatic amines and their application in organic synthesis[J]. Chemical Reagents, 1997, 19(1): 8-11 |
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| Authors: | Xiao Min Wu Xiaoping Liang Benxi Muramatsu Y Li Zhiliang |
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| Abstract: | Mannich reactions with aromatic amines and aromatic aldehydes and their applications were studied systematically. In this paper,a novel type of Mannich reactions with aromatic aldehydes and aromatic amines as well as 2-pentanone were performed at room temperature or slightly below in the presence of concentrated hydrochloric acid as the catalyst. More than ten related Mannich bases, 1-aryl-1-arylamino-3-hexanone, were synthesized with yields 62. 3% ~ 90. 4 %.Among the prepared Mannich bases there are morethan ten new compounds. |
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| Keywords: | Mannich reactions Mannich bases 2-pentanone aromatic amines aromatic aldehydes |
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