| 低温沉积制造壳聚糖-纳米羟基磷灰石支架 |
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| 引用本文： | 郑雄飞,翟文杰,梁迎春,孙涛.低温沉积制造壳聚糖-纳米羟基磷灰石支架[J].无机材料学报,2011,26(1):12-16. |
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| 作者姓名： | 郑雄飞 翟文杰 梁迎春 孙涛 |
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| 作者单位： | 哈尔滨工业大学 精密工程研究所, 哈尔滨 150001 |
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| 基金项目： | 哈尔滨市科技创新人才研究专项基金(2007RFXXS021)~~ |
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| 摘 要： | 为满足骨组织工程对支架孔隙可控及良好力学性能的要求, 基于低温沉积制造方法, 加工了壳聚糖-纳米羟基磷灰石多孔组织工程支架. 开发了载荷力挤出喷头, 实现了加工过程材料挤出的均匀性, 层与层粘接良好. 研究了支架分级结构的形成规律, 支架孔隙由大孔和微孔组成, 大孔完全联通, 且大小完全可控; 微孔由材料配比, 成型温度, 交联剂等参数影响, 较高的纳米羟基磷灰石含量获得较小的孔隙; 较低的成型温度获得更大的孔隙, 交联剂使微孔变小. 小鼠前成骨细胞系MC3T3-E1支架培养结果表明, 较高的纳米羟基磷灰石含量提高了支架的生物活性, 联通的大孔, 保证了细胞爬行至支架的中心位置.
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| 关 键 词： | 快速成型 低温沉积制造 支架 壳聚糖 纳米羟基磷灰石 |
| 收稿时间： | 2010-03-11 |
| 修稿时间： | 2010-04-21 |
Fabrication of Chitosan-nanohydroxyapatite Scaffolds via Low-temperature Deposition Manufacturing |
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| ZHENG Xiong-Fei,ZHAI Wen-Jie,LIANG Ying-Chun,SUN Tao.Fabrication of Chitosan-nanohydroxyapatite Scaffolds via Low-temperature Deposition Manufacturing[J].Journal of Inorganic Materials,2011,26(1):12-16. |
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| Authors: | ZHENG Xiong-Fei ZHAI Wen-Jie LIANG Ying-Chun SUN Tao |
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| Affiliation: | PrecisionEngineering Research Institute, Harbin Institute of Technology, Harbin 150001,China |
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| Abstract: | To meet the requirement of scaffold in bone tissue engineering with controllable macro and micro pores and good mechanical properties,chitosan-nanohydroxyapatite 3D porous scaffolds were fabricated by low-temperature deposition manufacturing.A load force driven injecting nozzle was proposed and developed to extrude natural derived polymers.Strand of biomaterials was extruded steady,uniformly and bonded to each other well.Hierarchial structure of scaffold was studied.Morphology of scaffold's pores contains m... |
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| Keywords: | rapid prototyping low-temperature deposition scaffold chitosan nano-hydroxyapatite |
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