| 具有良好贯通性的颗粒造孔支架的制备及表征 |
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| 引用本文： | 郭来阳,张靖微,赵婧,汪建新,翁杰,张聪. 具有良好贯通性的颗粒造孔支架的制备及表征[J]. 无机材料学报, 2011, 26(1): 17-21. DOI: 10.3724/SP.J.1077.2011.00017 |
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| 作者姓名： | 郭来阳 张靖微 赵婧 汪建新 翁杰 张聪 |
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| 作者单位： | 1. 材料先进技术教育部重点实验室, 西南交通大学 材料科学与工程学院, 成都610031; 2. 解放军第452医院, 成都610021 |
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| 基金项目： | 国家自然科学基金重点项目(30870630); 教育部高等学校博士学科专项科研基金(20070613062); 四川省科技计划项目(2008Jy0062)~~ |
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| 摘 要： | 支架孔隙贯通性的研究一直是多孔生物陶瓷的研究重点之一.采用石蜡球作为造孔剂, 在常规的颗粒造孔法制备多孔陶瓷支架的基础上,通过二甲苯处理以便在石蜡球间形成桥联结构, 以扩大颗粒间的接触面积,从而提高多孔陶瓷支架的孔隙贯通性. 借助扫描电镜(SEM)观察陶瓷支架的多孔结构,评价二甲苯处理石蜡球对陶瓷支架孔隙贯通性的改善效果; 采用密度法测定了陶瓷支架的孔隙率并计算其收缩率,并用成骨细胞评价陶瓷支架的细胞相容性. 结果表明,通过二甲苯的处理, 不仅改善了陶瓷支架孔隙的贯通性,而且提高了其孔隙率, 但孔隙率对陶瓷支架的收缩率无明显影响.细胞培养实验显示成骨细胞可进入多孔陶瓷支架内部, 并在材料表面正常生长,贯通性好的多孔陶瓷支架可为成骨细胞生长提供更充分的空间.
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| 关 键 词： | 多孔支架 颗粒造孔 贯通性 桥联结构 |
| 收稿时间： | 2010-02-09 |
| 修稿时间： | 2010-04-28 |
Preparation and Characterization of Porous Scaffolds with Favourable Interpore Connectivity |
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| GUO Lai-Yang,ZHANG Jing-Wei,ZHAO Jing,WANG Jian-Xin,WENG Jie,ZHANG Cong. Preparation and Characterization of Porous Scaffolds with Favourable Interpore Connectivity[J]. Journal of Inorganic Materials, 2011, 26(1): 17-21. DOI: 10.3724/SP.J.1077.2011.00017 |
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| Authors: | GUO Lai-Yang ZHANG Jing-Wei ZHAO Jing WANG Jian-Xin WENG Jie ZHANG Cong |
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| Affiliation: | 1. KeyLaboratory of Advanced Technologies of Materials, Ministry of Education, Schoolof Materials Science and Engineering, Southwest Jiaotong University, Chengdu610031, China; 2. 452nd Hospital of Chinese PLA, Chengdu 610021, China |
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| Abstract: | The pore interconnectivity is a key factor for the application of porous bioceramics as bone tissue engineering scaffolds.Packed wax spheres were treated with dimethyl benzene and acted as the porogen for the preparation of porous ceramic scaffolds,in order to increase the inter-sphere connectivity.The morphology,porosity, shrinkage,and the compressive strength of the obtained ceramic scaffolds were analyzed.The cell compatibility of the scaffolds was evaluated with Sprague-Dawley(SD) osteoblasts.The result... |
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| Keywords: | porous scaffolds particulate-leaching interpore connectivity bridging |
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