| 自固化硅羟基磷灰石骨水泥的制备及性能研究 |
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| 引用本文： | 苏佳灿,曹烈虎,禹宝庆,王志伟,陈晓,李明. 自固化硅羟基磷灰石骨水泥的制备及性能研究[J]. 无机材料学报, 2011, 26(1): 55-60. DOI: 10.3724/SP.J.1077.2011.00055 |
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| 作者姓名： | 苏佳灿 曹烈虎 禹宝庆 王志伟 陈晓 李明 |
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| 作者单位： | 上海市第二军医大学 附属长海医院 骨科, 上海 200433 |
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| 基金项目： | 上海市科委纳米专项基金(0852nm04300); 上海市人事局人才发展资金(2009003); 中国博士后基金(20100470756)~~ |
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| 摘 要： | 采用磷酸四钙和磷酸氢钙为羟基磷灰石水泥(HAC)粉末,5wt%硅酸钠水溶液为固化液, 制备了硅羟基磷灰石水泥(s-HAC). 结果显示: s-HAC的凝结时间和抗压强度性能明显优于以水为固化液的HAC. XRD和IR结果分析表明: s-HAC的最终水化产物为硅羟基磷灰石. s-HAC在Tris-HCl缓冲溶液中不仅能够释放出Ca、P离子,而且还能释放出Si离子, s-HAC的体外降解性优于HAC. 细胞培养实验显示: MG63细胞不仅能够在s-HAC和HAC表面粘附并保持正常的细胞形态; 而且MG63细胞在s-HAC上的光密度(OD)值和碱性磷酸酶(ALP)活性明显高于HAC, 这说明s-HAC能促进成骨细胞增殖和分化.
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| 关 键 词： | 硅羟基磷灰石 水泥 降解 细胞增殖 分化 |
| 收稿时间： | 2010-04-23 |
| 修稿时间： | 2010-09-03 |
Study on Preparation and Properties of Self-setting Silicon Hydroxyapatite Bone Cement |
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| SU Jia-Can,CAO Lie-Hu,YU Bao-Qing,WANG Zhi-Wei,CHEN Xiao,LI Ming. Study on Preparation and Properties of Self-setting Silicon Hydroxyapatite Bone Cement[J]. Journal of Inorganic Materials, 2011, 26(1): 55-60. DOI: 10.3724/SP.J.1077.2011.00055 |
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| Authors: | SU Jia-Can CAO Lie-Hu YU Bao-Qing WANG Zhi-Wei CHEN Xiao LI Ming |
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| Affiliation: | Department of Orthopaedics,Changhai Hospital, Second Military Medical University, Shanghai 200433, China |
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| Abstract: | Silicon hydroxyapatite cement(s-HAC) was prepared by using the mixed powders of tetracalcium phosphate and dicalcium phosphate anhydrous,and 5wt%sodium silicate water solutions as cement liquid.The results show that the setting time of s-HAC is shorter than hydroxyapatite cement(HAC),and the compressive strength of s-HAC is higher than HAC in the same situation.The XRD results reveal that the finally hardening product of s-HAC is hydroxyapatite structure,which is similar to that of HAC.The s-HAC in the coul... |
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| Keywords: | silicon hydroxyapatite cement degradation cell proliferation differentiation |
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