Comparison of skin-prick test and specific serum IgE determination for the diagnosis of latex allergy |
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| Authors: | C Blanco T Carrillo N Ortega M Alvarez C Dominguez R Castillo |
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| Affiliation: | Istituto di Farmacologia, Facoltà di Medicina, Università di Messina, Italy. |
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| Abstract: | The synthesis and anticonvulsant activity of novel 7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones 3a-e, structurally-related to GYKI 52466 1, a well-known noncompetitive AMPA-receptor antagonist, are reported. The new compounds possess marked anticonvulsant properties and, in analogy to 1, antagonize seizures induced by AMPA. In addition, when compared to the model compound 1, compounds 3 show a longer-lasting anticonvulsant activity and a lower toxicity. |
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