| Abstract: | In order to obtain more information about the in vivo mechanism of action of nitrosoureas, the synthesis of spin labelled nitrosoureas derived from 1-oxyl-2.2.6.6-tetramethyl-4-aminopiperidine was undertaken. The synthesis of four spin labelled ureas 4a–4d was reported as well as two spin labelled nitrosoureas:1-methyl-3-(2′.2′.6′.6.′-tetramethyl-piperidin-4′-yl-1′-oxyl)-1-nitrosourea( 9a ) and 1-(2′-chloroethyl)-3-(2″,2″.6″.6″-tetramethyl-piperidin-4″-yl-1″-oxyl)-nitrosourea (9b) . Their e.s.r. spectra were recorded. None of these compounds proved to be active against L1210. |
