Mining residue contacts in proteins using local structure predictions |
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Authors: | Zaki M.J. Shan Jin Bystroff C. |
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Affiliation: | Comput. Sci. Dept., Rensselaer Polytech. Inst., Troy, NY, USA. |
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Abstract: | In this paper we develop data mining techniques to predict 3D contact potentials among protein residues (or amino acids) based on the hierarchical nucleation-propagation model of protein folding. We apply a hybrid approach, using a hidden Markov model to extract folding initiation sites, and then apply association mining to discover contact potentials. The new hybrid approach achieves accuracy results better than those reported previously. |
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