Role of Acetic Acid Added to the Reaction Media for the
Enantio-differentiating Hydrogenation of Methyl Acetoacetate Over a Tartaric Acid-modified Nickel Catalyst |
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Authors: | Tsutomu Osawa Masashi Ando Saori Sakai Tadao Harada Osamu Takayasu |
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Affiliation: | (1) Faculty of Science, Toyama University, Toyama 930-8555, Japan;(2) Faculty of Science and Technology, Ryukoku University, Otsu 520-2194, Japan |
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Abstract: | The role of acetic acid added to the reaction media for the enantio-differentiating hydrogenation of methyl acetoacetate over
a (R,R)-tartaric acid-in-situ-modified nickel catalyst was studied from the viewpoint of the hydrogenation rate during repeated
runs. The hydrogenation of methyl acetoacetate on the “enantio-differentiating sites” of a tartaric acid-modified nickel catalyst
was specifically accelerated by the acetic acid added to the reaction media to increase the enantio-differentiating ability
of the catalyst. In order to increase the enantio-differentiating ability, the addition of acetic acid to the reaction media
was required in each run during the repeated use of the catalyst. |
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Keywords: | tartaric acid-modified nickel enantio-differentiating hydrogenation rate acetic acid site specific acceleration repeated uses |
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