| 模拟生物膜上铅离子毒性机理的研究 |
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| 引用本文： | 廖天录,孙国禄,董会平. 模拟生物膜上铅离子毒性机理的研究[J]. 广东化工, 2010, 37(1): 53-55 |
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| 作者姓名： | 廖天录 孙国禄 董会平 |
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| 作者单位： | 甘肃工业职业技术学院化学与环境工程系,甘肃天水,741025;甘肃工业职业技术学院化学与环境工程系,甘肃天水,741025;甘肃工业职业技术学院化学与环境工程系,甘肃天水,741025 |
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| 摘 要： | 以玻碳电极支撑的磷脂双层膜(s-BLM)作为生物膜的模型,Fe(CN)63-/4-为探针分子,利用循环伏安法和交流阻抗技术研究了铅离子与s-BLM的相互作用,结果表明,铅离子与s-BLM之间可以发生比较强烈的相互作用,诱发s-BLM上形成离子通道,并且作用后的s-BLM在10 mmol/L的乙二胺四乙酸(EDTA)溶液中能够自我修复,这表明采用强的鳌合剂从机体组织中将铅夺取,撤走铅离子则通道关闭。
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| 关 键 词： | 铅离子 循环伏安 交流阻抗 离子通道 支撑磷脂双层膜 |
Research on the Toxicity of Lead Ion in Mimetic Membrane |
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| Liao Tianlu,Sun Guolu,Dong Huiping. Research on the Toxicity of Lead Ion in Mimetic Membrane[J]. Guangdong Chemical Industry, 2010, 37(1): 53-55 |
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| Authors: | Liao Tianlu Sun Guolu Dong Huiping |
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| Affiliation: | Chemical and Environmental Engineering;Gansu Industing and Polytechnic College;Tianshui 741025;China |
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| Abstract: | In the paper,supported bilayer lipid membrane(s-BLM) was served as a biomembrane model and Fe(CN)63-/4-as the probe ion.The interaction between Pb2+ and s-BLM was investigated by means of cyclic voltammetry and ac impedance spectroscopy.The results showed that Pb2+ can decrease the orderliness of Phosphatidylcholine molecule and induce ion channel on s-BLM.The ion channel s-BLM after interaction can be self-repaired in 10 mmol/L EDTA solution,which indicated that the channel was in closed state in the absen... |
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| Keywords: | lead ion cyclic voltammetry A.C.impedance ion channel s-BLM |
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