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Highly Enantioselective Synthesis of 3‐Hydroxy‐2‐methylpropanoic Acid Esters through Ruthenium‐SYNPHOS®‐Catalyzed Hydrogenation: Useful Building Blocks for the Synthetic Community |
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| Authors: | Sé verine Jeulin,Tahar Ayad,Virginie Ratovelomanana‐Vidal,Jean‐Pierre Genê t |
| Abstract: | Both enantiomers of 3‐hydroxy‐2‐methylpropanoic acid tert‐butyl ester were prepared with high enantioselectivity (up to 94 %) through a ruthenium‐SYNPHOS®‐promoted asymmetric hydrogenation reaction using an atom‐economic transformation from simple and inexpensive precursors. |
| Keywords: | asymmetric catalysis hydrogenation Roche ester ruthenium |