A Highly Enantioselective Catalytic Domino Aza‐Michael/Aldol Reaction: One‐Pot Organocatalytic Asymmetric Synthesis of 1,2‐Dihydroquinolidines |
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Authors: | Henrik Sundé n,Ramon Rios,Ismail Ibrahem,Gui‐Ling Zhao,Lars Eriksson,Armando Có rdova |
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Abstract: | The highly enantioselective organocatalytic domino aza‐Michael/aldol reaction is presented. The unprecedented, chiral amine‐catalyzed asymmetric domino reactions between 2‐aminobenzaldehydes and α,β‐unsaturated aldehydes proceed with excellent chemo‐ and enantioselectivity to give the corresponding pharmaceutically valuable 1,2‐dihydroquinolines derivatives in high yields with 90 to >99 % ee. |
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Keywords: | asymmetric catalysis aza‐Michael reaction domino reactions nitrogen heterocycles α ,β ‐unsaturated aldehydes |
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