| 1-[3-(三氟甲基)苯基]-2-丙酮的合成新方法 |
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| 引用本文： | 李丽,林原斌. 1-[3-(三氟甲基)苯基]-2-丙酮的合成新方法[J]. 化学试剂, 2007, 29(7): 429-430 |
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| 作者姓名： | 李丽 林原斌 |
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| 作者单位： | 湖南科技大学,化学化工学院,湖南,湘潭,411201;湘潭大学,化学学院,湖南,湘潭,411105 |
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| 基金项目： | 国家自然科学基金资助项目(30470388) |
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| 摘 要： | 以间三氟甲基苯胺为起始原料,经重氮化反应和改进的Meerwein芳基化反应,制得1-[3-(三氟甲基)苯基]-2-丙酮。对反应条件进行了优化,在优化条件下的总收率可达90%。
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| 关 键 词： | 1-[3-(三氟甲基)苯基]-2-丙酮 氟硼酸重氮盐 改进的Meerwein芳基化反应 合成 |
| 文章编号： | 0258-3283（2007）07-0429-02 |
| 修稿时间： | 2007-01-08 |
Novel synthesis of 1-[3-(trifluoromethyl)phenyl]-2-propanone |
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| LI Li,LIN Yuan-bin. Novel synthesis of 1-[3-(trifluoromethyl)phenyl]-2-propanone[J]. Chemical Reagents, 2007, 29(7): 429-430 |
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| Authors: | LI Li LIN Yuan-bin |
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| Affiliation: | 1. School of Chemistry and Chemical Engineering, Hunan University of Science and Technol- ogy, Xiangtan 411201, China; 2. College of Chemistry, Xiangtan University, Xiangtan 411105, China |
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| Abstract: | A novel method was developed for the synthesis of 1-[3-(trifluoromethyl) phenyl]-2-propanone from m-trifluoromethylaniline by means of the diazotization reaction and an improved Meerwein arylation reaction under mild conditions.The reaction conditions were studied in detail.Under optimized conditions,the total yield could reach 90%. |
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| Keywords: | 1-[3-(trifluoromethyl) phenyl]-2-propanone diazonium tetrafluoroborate improved Meerwein arylation reaction synthesis |
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