| 1,3-二乙酰氧基-2-乙酰氧基甲氧基丙烷的合成 |
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| 引用本文： | 陈文华. 1,3-二乙酰氧基-2-乙酰氧基甲氧基丙烷的合成[J]. 化学试剂, 2007, 29(2): 119-120 |
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| 作者姓名： | 陈文华 |
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| 作者单位： | 常州工程职业技术学院,应用化学系,江苏,常州,213164 |
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| 摘 要： | 以环氧氯丙烷为起始原料与浓盐酸反应制得1,3-二氯-2-丙醇,再在浓硫酸催化下与多聚甲醛缩合得1,3-二氯-2-丙醇的半缩甲醛,不经分离,直接用醋酐酰化得1,3-二氯-2-乙酰氧基甲氧基丙烷,后者与醋酸钠反应得标题化合物。以环氧氯丙烷计4步反应总收率为55.6%。
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| 关 键 词： | 1 3-二乙酰氧基-2-乙酰氧基甲氧基丙烷 环氧氯丙烷 更昔洛韦 合成 |
| 文章编号： | 0258-3283（2007）02-0119-02 |
| 修稿时间： | 2006-07-28 |
Synthesis of 2-(acetoxymethoxy)-1,3-diacetoxypropane |
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| CHEN Wen-hua. Synthesis of 2-(acetoxymethoxy)-1,3-diacetoxypropane[J]. Chemical Reagents, 2007, 29(2): 119-120 |
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| Authors: | CHEN Wen-hua |
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| Affiliation: | Department of Applied Chemistry, Changzhou Vocational College of Engineering and Technology, Changzhou 213164, China |
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| Abstract: | 3-Chloro-1,2-epoxypropane was used as the starting material in the reaction with concentrated hydrochloric acid to yield 1,3-dichloro-2-propanol.The reaction of 1,3-dichloro-2-propanol with polyformaldehyde in the presence of concentrated sulfuric acid gave 1,3-dichloro-2-(hydroxymethyoxy)propane,which without being separated from the reaction mixture entered into reaction with acetic anhydride to give 2-(acetoxymethoxy)-1,3-dichloropropane.Furthermore,it reacted with sodium acetate to give 2-(acetoxymethoxy)-1,3-diacetoxypropane.The overall yield of 1 based on 3-chloro-1,2-epoxypropane was approximately 55.6%. |
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| Keywords: | 2-(acetoxymethoxy)-1 3-diacetoxypropane 3-chloro-1 2-epoxypropane Genciclovir synthesis |
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