| 2-丙基-4-[(1-羟基-1-甲基)乙基]-1H-咪唑-5-羧酸乙酯的合成 |
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| 引用本文： | 王尊元,张萍,梁美好,沈正荣.2-丙基-4-[(1-羟基-1-甲基)乙基]-1H-咪唑-5-羧酸乙酯的合成[J].化学试剂,2007,29(11):679-680. |
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| 作者姓名： | 王尊元 张萍 梁美好 沈正荣 |
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| 作者单位： | 浙江省医学科学院,药物研究所,浙江,杭州,310013;浙江省医学科学院,药物研究所,浙江,杭州,310013;浙江省医学科学院,药物研究所,浙江,杭州,310013;浙江省医学科学院,药物研究所,浙江,杭州,310013 |
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| 基金项目： | 浙江省科技厅面上项目(2005F13G5250019) |
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| 摘 要： | 用正丁酸与邻苯二胺为原料,在微波照射下缩合成2-丙基苯并咪唑,再氧化开环制得2-丙基咪唑二羧酸,再经酯化、Gringard反应制得抗高血压药物奥美沙坦的关键中间体2-丙基-4-(1-羟基-1-甲基)乙基]-1H-咪唑-5-羧酸乙酯,总收率32.2%。
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| 关 键 词： | 2-丙基-4-[(1-羟基-1-甲基)乙基]-1H-咪唑-5-羧酸乙酯 奥美沙坦 中间体 合成 |
| 文章编号： | 0258-3283（2007）11-0679-02 |
| 修稿时间： | 2007-05-07 |
Synthesis of ethyl 4-[(1-hydroxy-1-methyl)ethyl]-2-propyl-1H-imidazole-5-carboxylate |
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| WANG Zun-yuan,ZHANG Ping,LIANG Mei-hao,SHEN Zheng-rong.Synthesis of ethyl 4-[(1-hydroxy-1-methyl)ethyl]-2-propyl-1H-imidazole-5-carboxylate[J].Chemical Reagents,2007,29(11):679-680. |
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| Authors: | WANG Zun-yuan ZHANG Ping LIANG Mei-hao SHEN Zheng-rong |
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| Affiliation: | Institute of Medicinal Materials,Zhejiang Academy of Medical Sciences,Hangzhou 310013,China |
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| Abstract: | Ethyl 4-(1-hydroxy-1-methyl)ethyl]-2-propyl-1H-imidazole-5-carboxylate,the key intermediate of Olmesartan,was synthesized from butanoic acid and o-phenylenediamine via condensation under microwave-irradiation,oxidation,esterification and the Gringard reaction.The overall yield of target product was 32.2%. |
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| Keywords: | ethyl 4-[(1-hydroxy-1-methyl)ethyl]-2-propyl-1H-imidazole-5-carboxylate Olmesartan intermediate synthesis |
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