| 烷氧基卤代吡啶及其二苯基膦衍生物的合成研究 |
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| 引用本文： | 刘洁,王越,齐艳,明媚,陈煦.烷氧基卤代吡啶及其二苯基膦衍生物的合成研究[J].化学试剂,2007,29(4):193-196,206. |
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| 作者姓名： | 刘洁 王越 齐艳 明媚 陈煦 |
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| 作者单位： | 天津师范大学,化学与生命科学学院,天津,300074 |
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| 摘 要： | 设计合成了新型手性催化剂的中间体。以氯代吡啶为原料,经烷氧基取代,选择性单溴代,合成了系列烷氧基溴代吡啶,最后利用锂化反应的区域选择性,制备了二苯基膦烷氧基溴代吡啶;并对反应选择性进行了重点讨论。
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| 关 键 词： | 烷氧基吡啶 烷氧基溴代吡啶 二苯基膦烷氧基溴代吡啶 锂化反应 区域选择性 |
| 文章编号： | 0258-3283（2007）04-0193-04 |
| 修稿时间： | 2006-09-22 |
Synthesis of alkyloxypyridine bromide and its diphenylphosphine derivatives |
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| LIU Jie,WANG Yue,QI Yan,MING Mei,CHEN Xu.Synthesis of alkyloxypyridine bromide and its diphenylphosphine derivatives[J].Chemical Reagents,2007,29(4):193-196,206. |
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| Authors: | LIU Jie WANG Yue QI Yan MING Mei CHEN Xu |
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| Affiliation: | Chemistry and Life Sciences College, Tianjin Norreal University, Tianjin 300074, China |
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| Abstract: | As novel intermediates for chiral catalysts,a series of mono-and di-alkyloxypyridine bromide(5 and 2) were synthesized from the 2-cholopyridine and 2,6-dichlorpyridine by the reaction of alkyloxy-substitution and selective mono-bromination,respectively.Then,the regioselective ortho lithiation of alkyloxypyridine bromide was further performed to produce the diphenylphosphine alkyloxypyridine bromide derivatives(3a,3b and 6a).In addition,the regioselectivity of lithiation was also discussed in detail in the paper. |
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| Keywords: | alkyloxypyridine alkyloxypyridine bromide diphe-nylphosphino-bromo-alkyloxy-pridine lithiation reaction regioselectivity |
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