| 扁桃酸的拆分和手性扁桃酸的合成研究进展 |
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| 引用本文： | 邵恒,甘永平,张文魁,黄辉,叶张军. 扁桃酸的拆分和手性扁桃酸的合成研究进展[J]. 化学试剂, 2007, 29(3): 143-146,153 |
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| 作者姓名： | 邵恒 甘永平 张文魁 黄辉 叶张军 |
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| 作者单位： | 浙江工业大学,化工与材料学院,浙江,杭州,310032;浙江工业大学,化工与材料学院,浙江,杭州,310032;浙江工业大学,化工与材料学院,浙江,杭州,310032;浙江工业大学,化工与材料学院,浙江,杭州,310032;浙江工业大学,化工与材料学院,浙江,杭州,310032 |
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| 摘 要： | 综述了扁桃酸拆分和手性扁桃酸合成的研究进展,对非对映体盐结晶法、萃取法、色谱法、电泳法、酶催化法拆分消旋扁桃酸的原理、工艺和特点进行了评述,并介绍了生物转化法、电化学法和直接化学法合成手性扁桃酸的研究状况。其中非对映体盐结晶法是目前工业生产手性扁桃酸的重要方法,而生物转化法合成手性扁桃酸具有良好的工业应用前景。
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| 关 键 词： | 手性扁桃酸 拆分 合成 |
| 文章编号： | 0258-3283（2007）03-0143-04 |
| 修稿时间： | 2006-08-26 |
Advances in resolution of mandelic acid and synthesis of chiral mandelic acid |
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| SHAO Heng,GAN Yong-ping,ZHANG Wen-kui,HUANG Hui,YE Zhang-jun. Advances in resolution of mandelic acid and synthesis of chiral mandelic acid[J]. Chemical Reagents, 2007, 29(3): 143-146,153 |
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| Authors: | SHAO Heng GAN Yong-ping ZHANG Wen-kui HUANG Hui YE Zhang-jun |
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| Affiliation: | College of Chemical Engineering and Materials Science, Zhejiang University of Technology,Hangzhou 310032, China |
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| Abstract: | The research progress on resolution of DL-mandelic acid and synthesis of optically active mandelic acid was summarized.The resolution principles,techniques and characteristics of various methods including diastereomeric salt crystallization,extraction,chromatography,electrophoresis and enzymatic catalysis were reviewed.The research advances in the synthesis of optically active mandelic acid by biotransformation,electrochemistry and direct chemical method were also introduced.Among these methods,the diastereomeric salt crystallization is an important method to produce optically active mandelic acid in commercial scale,and also the biotransformation method has a good prospect for commercial application. |
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| Keywords: | chiral mandelic acid resolution synthesis |
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