| "链接"化学及其在药物研究中的应用 |
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| 引用本文： | 胡君,李映,凌云,杨新玲. "链接"化学及其在药物研究中的应用[J]. 化学试剂, 2007, 29(4): 207-211,228 |
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| 作者姓名： | 胡君 李映 凌云 杨新玲 |
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| 作者单位： | 中国农业大学,应用化学系,北京,100094;中国农业大学,应用化学系,北京,100094;中国农业大学,应用化学系,北京,100094;中国农业大学,应用化学系,北京,100094 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)资助项目(2003CB114400) |
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| 摘 要： | 介绍了“链接”化学(Click Chemistry)的产生背景、基本概念、反应特点及类型,综述了近年来“链接”化学作为一种新型的组合合成方法在合成先导化合物库、标记蛋白质及DNA等方面的应用,并对“链接”化学的发展前景作了展望。
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| 关 键 词： | " 链接" 化学 药物研究 合成 |
| 文章编号： | 0258-3283（2007）04-0207-05 |
| 修稿时间： | 2006-10-19 |
Click chemistry and its applications in drug research |
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| HU Jun,LI Ying,LING Yun,YANG Xin-ling. Click chemistry and its applications in drug research[J]. Chemical Reagents, 2007, 29(4): 207-211,228 |
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| Authors: | HU Jun LI Ying LING Yun YANG Xin-ling |
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| Affiliation: | Department of Applied Chemistry, China Agricultural University, Beijing 100094,China |
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| Abstract: | In this review,the background and basic concepts of click chemistry are introduced,and also the specific features of click chemistry and some classic examples of click chemistry are presented.As a new type of synthetic method,click chemistry has been used in synthesizing lead discovery libraries,profiling protein in vivo and labeling DNA and so on.At last,the possible future of click chemistry is reviewed. |
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| Keywords: | click chemistry drug research synthesis |
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