| 吲唑的简便合成 |
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| 引用本文： | 蔡可迎,宗志敏,魏贤勇. 吲唑的简便合成[J]. 化学试剂, 2007, 29(1): 53-54 |
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| 作者姓名： | 蔡可迎 宗志敏 魏贤勇 |
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| 作者单位： | 中国矿业大学,化工学院,江苏,徐州,221008;中国矿业大学,化工学院,江苏,徐州,221008;中国矿业大学,化工学院,江苏,徐州,221008 |
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| 基金项目： | 江苏省高新技术产业发展项目(JHB05-33) |
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| 摘 要： | 以邻硝基甲苯为原料,在乙醇钠催化下与草酸二乙酯缩合,然后经水解、双氧水氧化、盐酸酸化得到邻硝基苯乙酸,收率62%。邻硝基苯乙酸用8%硫化铵溶液在回流温度下还原2 h后再进行重氮化反应,将得到的重氮盐溶液于室温放置24 h得到吲唑,收率71%。两步总收率44%。
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| 关 键 词： | 吲唑 邻硝基苯乙酸 合成 |
| 文章编号： | 0258-3283（2007）01-0053-02 |
| 修稿时间： | 2006-05-25 |
Simple synthesis of indazole |
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| CAI Ke -ying,ZONG Zhi-min,WEI Xian-yong. Simple synthesis of indazole[J]. Chemical Reagents, 2007, 29(1): 53-54 |
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| Authors: | CAI Ke -ying ZONG Zhi-min WEI Xian-yong |
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| Affiliation: | School of Chemical Engineering, China University of Mining and Technology, Xuzhou 221008, China |
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| Abstract: | o-Nitrophenylacetic acid was synthesized by condensation of o-nitrotoluene with diethyl oxalate catalyzed by C_2H_5ONa,followed by hydrolysis,oxidation with H_2O_2 and acidification with HCl,resulting in an approximate 62% yield.Indazole was synthesized in 71% yield by keeping the diazonation solution for 24 h at room temperature,which was prepared from reducing o-nitrophenylacetic acid with 8%(NH_4)_2S solution upon refluxing for(2 h) and diazotizing with HCl and NaNO_2.The overall yield was around 44%. |
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| Keywords: | indazole o-nitrophenylacetic acid synthesis |
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