Improvements in microstructural,mechanical, and biocompatibility properties of nano-sized hydroxyapatites doped with yttrium and fluoride |
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Authors: | Burcin Basar Aysen Tezcaner Dilek Keskin Zafer Evis |
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Affiliation: | 1. Middle East Technical University, Department of Engineering Sciences, Ankara 06531, Turkey;2. Middle East Technical University, Graduate Department of Biomedical Engineering, Ankara 06531, Turkey |
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Abstract: | Hydroxyapatite was doped with Y3+ (2.5, 5 and 7.5 mol%) and F− (2.5 mol%) ions (2.5YFHA, 5YFHA, 7.5YFHA, respectively) to compare its structural and mechanical properties and cellular response with pure-hydroxyapatite. No second phases were observed by X-ray diffraction spectra of 2.5YFHA. Doped hydroxyapatites had F− bonds in addition to OH− bonds. Hydroxyapatites sintered at 900 and 1100 °C were in nano-size. 7.5YFHA sintered at 1300 °C had the highest microhardness value. 2.5YFHA sintered at 1100 °C had the highest fracture toughness value. MTT viability assays showed high cell attachments on 2.5YFHA. Cell proliferation on 2.5YFHA and 5YFHA sintered at 1100 and 1300 °C was comparable with the control after 5-day culture. The highest ALP production and calcium deposition were observed on all hydroxyapatites sintered at 1100 °C. 2.5YFHA sintered at 1100 °C can be an alternative for hydroxyapatite in orthopedic applications. |
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Keywords: | A Sintering B X-ray methods C Hardness D Apatite E Biomedical applications |
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