Electrospun nanofibrous biodegradable polyester coatings on Bioglass-based glass-ceramics for tissue engineering |
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| Authors: | Oana Bretcanu Superb K Misra D Mohammad Yunos Aldo R Boccaccini Ipsita Roy Tomasz Kowalczyk Slawomir Blonski Tomasz A Kowalewski |
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| Affiliation: | aDepartment of Materials, Imperial College London, UK;bDepartment of Molecular and Applied Biosciences, University of Westminster, UK;cInstitute of Fundamental Technology Research Polish Academy of Sciences (IPPT PAN), Warsaw, Poland |
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| Abstract: | Biodegradable polymeric nanofibrous coatings were obtained by electrospinning different polymers onto sintered 45S5 Bioglass®-based glass-ceramic pellets. The investigated polymers were poly(3-hydroxybutyrate) (P3HB), poly(3-hydroxybutyrate-co-hydroxyvalerate) (PHBV) and a composite of poly(caprolactone) (PCL) and poly(ethylene oxide) (PEO) (PCL–PEO). The fibrous coatings morphology was evaluated by optical microscopy and scanning electron microscopy. The electrospinning process parameters were optimised to obtain reproducible coatings formed by a thin web of polymer nanofibres. In-vitro studies in simulated body fluid (SBF) were performed to investigate the bioactivity and mineralisation of the substrates by inducing the formation of hydroxyapatite (HA) on the nanofiber-coated pellets. HA crystals were detected on all samples after 7 days of immersion in SBF, however the morphology of the HA layer depended on the characteristic fibre diameter, which in turn was a function of the specific polymer-solvent system used. The bioactive and resorbable nanofibrous coatings can be used to tailor the surface topography of bioactive glass-ceramics for applications in tissue engineering scaffolds. |
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| Keywords: | Electrospinning Nanofibers Bioglass® Polyhydroxyalkanoates Tissue engineering |
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