| 阿糖胞苷诱发小鼠血小板减少模型的研究 |
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| 引用本文： | 徐国良,肖兵华,陈奇,徐友妹.阿糖胞苷诱发小鼠血小板减少模型的研究[J].金属学报,2005,10(4):387-390. |
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| 作者姓名： | 徐国良 肖兵华 陈奇 徐友妹 |
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| 作者单位： | 江西江中药业有限公司, 南昌 330077,江西;1.江西中医学院中药药理教研室, ;2.附属医院检验科, 南昌 330006, 江西 |
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| 基金项目： | 国家自然科学基金课题(NO30260122); 江西省教育厅课题(NO237B03) |
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| 摘 要： | 目的: 建立阿糖胞苷诱发时间更快和更稳定的小鼠血小板减少模型。方法: 小鼠腹腔分别注射200 和100mg°kg-1 阿糖胞苷, 造成血小板减少, 观察两组动物外周血象 、骨髓涂片和脾脏、肾上腺、胸腺重量的变化。结果: 两种剂量的阿糖胞苷都能成功造成小鼠血小板减少模型, 在诱发时间和稳定性方面200 mg°kg-1 阿糖胞苷组优于 100 mg°kg-1 阿糖胞苷组, 除血小板数之外,两剂量组的其它观察指标无明显区别。结论: 200 mg°kg-1 阿糖胞苷组造成的小鼠血小板减少模型诱发时间更快、稳定性更好。
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| 关 键 词： | 阿糖胞苷 血小板减少模型 骨髓巨核细胞数 动物模型 免疫抑制 |
| 收稿时间： | 2004-12-20 |
| 修稿时间： | 2005-03-18 |
Establishment of mouse model of Cytosine arabinoside-induced thrombocy-topenia |
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| XU Guo-liang,XIAO Bing-hua,CHEN Qi,XU You-mei.Establishment of mouse model of Cytosine arabinoside-induced thrombocy-topenia[J].Acta Metallurgica Sinica,2005,10(4):387-390. |
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| Authors: | XU Guo-liang XIAO Bing-hua CHEN Qi XU You-mei |
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| Affiliation: | Jiangxi Jangzhong Pharmaceuticals Co.LTT, Nanchang330077, Jiangxi, China;1.Department of TCM Pharmacology, Jiangxi College of TCM;2.Affliated Hospital of Jiangxi College of TCM, Nanchang330006, Jiangxi, China |
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| Abstract: | AIM: To establish a mouse model of cy-tosine arabinoside (Ara-c) induced thrombocytopenia which leads inducement time more quickly and stably. METHODS: The mice were injected different dosages cytosine arabinoside (Ara-c)in two groups, respectively. The change of thrombocytopenia was observed in peripher-al hemogram and smear of marrow, andweightsof spleen, adrenal gland and thymus gland also were observed. RESULTS: The high dosage (200 mg°kg-1)to the model formation was better than low dosage (100 mg°kg-1)at inducement time and stability. The index showed no sig-nificant different between two groups except the volume of thrombocyte. CONCLUSION: Cytosine arabinoside-in-duced thrombocytopenia at high dosage (200 mg°kg-1) can induce thrombocytopenia more effectively. |
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| Keywords: | cytosine arabinoside (Ara-c) animal model thrombocytopenia megakaryocyte immunosup-pression |
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