| 糖尿病肾病中转化生长因子-β1 信号转导与肾纤维化 |
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| 引用本文： | 汪建云,印晓星. 糖尿病肾病中转化生长因子-β1 信号转导与肾纤维化[J]. 金属学报, 2005, 10(4): 371-376 |
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| 作者姓名： | 汪建云 印晓星 |
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| 作者单位： | 徐州医学院药学系,徐州 221002,江苏 |
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| 基金项目： | 江苏省高校自然科研基金课题(NO03KJ13360143) |
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| 摘 要： | 糖尿病肾病是终末期肾衰的主要原因之一, 其主要病理特征为肾纤维化, 转化生长因子-β1 是其肾纤维化过程中的核心因子。转化生长因子-β1 下游的两条信号通路Smads、MAPK 与肾纤维化过程中ECM 的堆积密切相关。两种信号通路相互作用, 共同促进肾纤维化的发展。真正理解它们之间的关系为糖尿病肾病的治疗提供了一个新的思路。
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| 关 键 词： | 糖尿病肾病 转化生长因子-β1 肾纤维化 Smads MAPK |
| 收稿时间： | 2005-01-31 |
| 修稿时间： | 2005-03-16 |
Relationship between transforming growth factor-β1 signal transduction and renal fibrosis of diabetes |
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| WANG Jian-yun,YIN Xiao-xing. Relationship between transforming growth factor-β1 signal transduction and renal fibrosis of diabetes[J]. Acta Metallurgica Sinica, 2005, 10(4): 371-376 |
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| Authors: | WANG Jian-yun YIN Xiao-xing |
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| Affiliation: | Department of Pharmacy, Xuzhou Medical College, Xuzhou 221002, Jiangsu, China |
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| Abstract: | Diabetic nephropathy is one of the leading causes of the end-stage renal failure, and its major patho-logic feature is the renal fibrosis.Transforming growth factor-β1 is a key factor in the progression of the disease. Two signal pathways, Smads and MAPK following the fac-tor, are closely connected with extracellular matrix accu-mulationwhich leads to renal fibrosis.Smads and MAPK also have a cross talk in extracellular matrix accumula-tion.The relationship between the two signal pathway and ECM accumulation offers us a new therapeutic strategy for renal fibrosis of diabetes. |
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| Keywords: | diabetic nephropathy transforming growth factor-β1 renal fibrosis Smads MAPK |
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