咪唑安定、芬大尼、异丙酚联合诱导时对镇静催眠作用的影响

目的: 采用权重配方法分析咪唑安定(Mid)、芬太尼(Fen)和异丙酚(Pro)联合诱导时在镇静、催眼上相互作用的性质,方法:60例美国麻醉协会(ASA)分级I-II级的择期行腹腔镜手术的病人根据权重配方法设计,均匀分配至6个不同剂量水平不同的用药组(配伍组1 ~6),麻醉诱导为依次注入Mid(15 s),Fen(15 s),Pro(30 s)和罗库溴铵0.6mg·kg^-1。Pro注入后3 min行气管插管。记录诱导前、异丙酚注入后1、2 min、插管即刻、插管后1、3、5、7min的脑电双频谱指数(BIS)、平均动脉压(MAP)、心率(HR)值。结果: 配伍组1的诱导期BIS变化值较为理想。结论: Mid、Fen和 Pro 在镇静催眠上呈相加作用,理想的诱导剂量为Mid 0.02 mg·kg^-1、 Fen 0.0025 mg·kg^-1、Pro 0.8 mg·kg^-1。

Effect of midazolam,fentanyl and propofol coinduction on hypnotic andsedation in gengerl anesthesia

AIM: To investigate hypnotic and seda-lion interaction between midazolam, fentanyl and propofolin coinduction in general anesthesia.METHODS: Sixty patients', ASA class I orll, scheduled for elective celo Nc ope (peration were evenly distributed to 6 different com-pound dose groups according to weighted modificationmethodl Anesthesia was induced with midazolam which was administered over 15 s, and fentanyl which was administered over 15 s, and propofol which was administerel over 30 s. then monium 0.6 mg·kg^-1 was adwinisteredl to facilitate tracheal intubation. BIS, MAPHR were recorded at following times: before induction, Iand 2 tnin after induction, just at intubation, I and 3 and 5 and 7 min after intubation.RESULTS: The importantdegree of every drug was as follow: propofol > nltanylmidazolam. The optimal combinations was midazolam 0.02 mg·kg^-1, fentanyl 0.0025 mg·kg^-1 and propofol 0.8 mg·kg^-1. The optimal ratio was 1.0. 0.125: 40. Thenature of interaction was additive.CONCLUSION: Themidazolam, fentanyl and propofol combination possess ad-dtitive interaction in sedation and hypnosis. The optimcombinations was midazolam 0.02 mg·kg^-1, fentanyl 0.0025 mg·kg^-1 and propofol 0.8 mg·kg^-1.