| 奥美拉唑与其他药物治疗消化性溃疡及出血对照研究Meta 分析 |
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| 引用本文： | 陈永荣. 奥美拉唑与其他药物治疗消化性溃疡及出血对照研究Meta 分析[J]. 金属学报, 2005, 10(12): 1420-1422 |
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| 作者姓名： | 陈永荣 |
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| 作者单位： | 六安市中医院药剂科, 六安 237006, 安徽 |
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| 摘 要： | 目的: 了解奥美拉唑(Omeprazole,Om) 与其他药物治疗消化性溃疡及出血疗效的差异。方法: 应用Meta 分析对9 项研究消化性溃疡及出血的效果进行同质性检验和合并效应量的估计。结果: (1) 同质性检验:χ2 =9.84,自由度8,P>0.05 。(2) 合并效应量的估计:OR合并95 %可信区间为2.83 ~ 6.68 。OR合并的检验:χ2 =44.4,P<0.01 。结论: 奥美拉唑治疗消化性溃疡及出血的疗效优于目前常用药物,Om 在治疗消化道溃疡及出血疗效方面较其他已上市药物都要好,且无明显不良反应,值得临床推广。
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| 关 键 词： | 奥美拉唑 消化性溃疡 Meta 分析 临床试验 比数比 |
| 收稿时间： | 2005-10-20 |
| 修稿时间： | 2005-11-15 |
Meta-analysis of effectiveness of omeprazole and otherdrugs in treatment of active peptic ulcerand bleeding |
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| CHEN Yong-rong. Meta-analysis of effectiveness of omeprazole and otherdrugs in treatment of active peptic ulcerand bleeding[J]. Acta Metallurgica Sinica, 2005, 10(12): 1420-1422 |
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| Authors: | CHEN Yong-rong |
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| Affiliation: | Department of Pharmacy,the Traditional Hospital of Luan,Luan 237006,Anhui |
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| Abstract: | AIM: To explore the difference of efficacy between omeprazole and otherdrugs in treatment of active peptic ulcerand bleeding.METHODS: The efficacy of omeprazole orotherdrugs in treatment of active peptic ulcerand bleeding was analyzed by Meta-analysis in homogeneity test and combined test in 9 studies.RESULTS: Homogeneity test showed that the cited studies were homogeneous withχ2 =9.84,P>0.05;and in combined test,the combined Or=4.42 and its 95 %confidence interval was in 2.83-6.68 (χ2=44.4,P<0.01).CONCLUSION: Omeprazole is a very effective and well-tolerated proton pumPinhibitorand it is worthy of being recommended foradministration in patients with active peptic ulcerand bleeding. |
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| Keywords: | active peptic ulcerand bleeding omeprazole Meta-analysis clinical trial |
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