苦参素胶囊联合复方丹参滴丸治疗乙肝后肝纤维化的临床研究

目的: 观察苦参素胶囊联合复方丹参滴丸对慢性乙肝肝纤维化的治疗效果。方法: 54 例慢性乙肝肝纤维化患者随机分为对照组和联合治疗组, 观察治疗前、后肝功能、肝纤维化指标和 HBV 标志物的变化。结果: 治疗后联合治疗组各项指标均较治疗前及对照组有明显改善(P<0.05 或 P<0.01)。结论: 苦参素胶囊联合复方丹参滴丸可明显控制乙肝患者的肝脏炎症, 显著提高抗肝纤维化作用, 可抑制HBV 复制且无严重不良反应。

Clinical evaluation on marine capsules combined with the composite Salvia miltiorrhiza dropping pill in treatment of patients with cirrhosis related to chronic hepatitis B

AIM: To investigate the therapeutic ef-fects of the marine capsules combined with composite Salvia miltiorrhiza dropping pill in treatment with patients with hepatic fibrosis related to chronic hepatitis B. METHODS: 54 patients were enrolled and randomly di-vided into control group and treatment group.The liver function, the marker of hepatic fibrosis and hepatitis B virus were determined before and after therapy. RESULTS: The markers in this study were significantly im-proved than those before treatment and those in control group (P<0.05 or P<0.01). CONCLUSION: The marine capsules combined with composite Salvia miltior-rhiza dropping pill can effectively control the activity of liver inflammation in the patients with chronic hepatitis B and markedly heighten the effects in treatment of patients with hepatic fibrosis and inhibit the replication of HBV without severe side effect.