| 四氢生物蝶呤对大鼠肾缺血再灌注损伤的作用 |
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| 引用本文： | 张艳青,张英,王顺蓉,李著华.四氢生物蝶呤对大鼠肾缺血再灌注损伤的作用[J].金属学报,2005,10(2):172-175. |
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| 作者姓名： | 张艳青 张英 王顺蓉 李著华 |
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| 作者单位： | 扬州大学医学院病理生理教研室, 扬州225001, 江苏;1.泸州医学院病理生理教研室, 泸州646000, 四川 |
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| 摘 要： | 目的:探讨四氢生物蝶呤(BH4) 对肾缺血再灌注损伤(IR) 模型的作用及其作用机制。方法:复制大鼠肾缺血再灌注模型, 手术前1 h 喂饲BH4, 动态检测其对肾组织NO 含量、cNOS 和iNOS 活性的影响, 并通过肾功能、MPO、MDA 的变化来评价BH4 对肾IR 模型的作用。结果:BH4 能够升高再灌注早期cNOS 活性, 增加内皮源性NO 含量, 减轻炎症反应,减弱再灌注后期对iNOS 的诱导作用。结论:BH4 可改善再灌注初期cNOS 活性, 保护肾功能。
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| 关 键 词： | 四氢生物蝶呤 一氧化氮 肾脏 大鼠 缺血再灌注损伤 |
| 收稿时间： | 2004-11-04 |
| 修稿时间： | 2005-01-03 |
Effects of tetrahydrobiopterin on renal ischemia-reperfusion injury in rats |
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| ZHANG Yan-qing,ZHANG Ying,WANG Shun-rong,LI Zhu-hua.Effects of tetrahydrobiopterin on renal ischemia-reperfusion injury in rats[J].Acta Metallurgica Sinica,2005,10(2):172-175. |
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| Authors: | ZHANG Yan-qing ZHANG Ying WANG Shun-rong LI Zhu-hua |
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| Affiliation: | Department of Pathophysiology, Yangzhou University, Yangzhou 225001, Jiangsu, China;1.Department of Pathophysiology, Luzhou Medical College, Luzhou 646000, Sichuan, China |
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| Abstract: | AIM: To investigate the effects and mechanisms of tetrahydrobiopterin (BH4) on renal ischemia-reperfusion injury in rats.METHODS: The ischemia-reperfusion model was induced and 20 mg°kg-1 BH4 was orally administrated 1 h before the operation.NO, NOS activity, MPO activity and MDA and renal function were measured in order to assess the efficacy of BH4. RESULTS: BH4 ameliorated cNOS during the early period of reperfusion and increased the NO level in renal tissue which diminish inflammation responses and decrease the induction of iNOS.CONCLUSION: BH4 can attenuate renal ischemia-reperfusion injury, and it may be related to ameliorating cNOS during the early period of reperfusion. |
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| Keywords: | tetrahydrobiopterin nitric oxide renal ischemia-reperfusion injury rats |
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