Identification of novel genes that are differentially expressed in human colorectal carcinoma |
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Authors: | EC Chan MY Lue KC Hsu HA Fan |
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Affiliation: | Laboratorio de Biología Molecular, Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Argentina. |
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Abstract: | To investigate the origin of fragile X mutations in the Argentine population, we studied the alleles and haplotypes at DXS548 and FRAXAC1 loci of 42 unrelated fragile X chromosomes and 168 normal ones. Four haplotypes presented in linkage disequilibrium and accounted for 76.2% of fragile X chromosomes, representing the high frequency of haplotype DXS548-FRAXAC1 7-1 (26.2%) characteristic of our population. FRAXAC1 allele 1 was observed on 47.6% of fragile X chromosomes. Thus, we provide evidence for fragile X founder effects in the Argentine population, similar to those observed in Caucasians and in Asians. |
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