超临界CO_2及超临界CO_2/乙醇中磷脂酰胆碱的溶解度

利用动态法测定了磷脂酰胆碱(PC)在超临界CO2(SC-CO2)及超临界CO2/乙醇体系中的溶解度。在15~30 MPa压力(p)、313~343 K温度(T)条件下,PC在SC-CO2中的溶解度为x1(PC)=10-6~10-5,在SC-CO2/乙醇多元体系中,PC溶解度x2(PC)可提高至10-4。PC的溶解度与c(CO2)(d)、x(CH3CH2OH)(c)呈指数相关性。根据缔合反应规则,建立了质量作用模型x1(PC)=d3.89e(-2383.63/T-41.64)、x2(PC)=d3.17c0.36e(-1748.03/T-33.73),分别关联PC在SC-CO2、SC-CO2/乙醇中的溶解度,模型计算结果与溶解度实验数据较好吻合,关联误差(AARD)分别为4.31%、3.78%。

Solubility of Phosphatidylcholine in Supercritical Carbon Dioxide and Supercritical Carbon Dioxide/Ethanol Mixture

The solubility of phosphatidylcholine(PC) in supercritical carbon dioxide(SC-CO2) with and without ethanol were determined by a dynamic method.The solubility in SC-CO2 x1(PC)]were from 10-6 to 10-5,while x2(PC) were enhanced up to 10-4 in SC-CO2 with cosolvent of ethanol at pressure(P) of 15～30 MPa and temperature(T) of 313～343 K.The solubility data were related exponentially with both c(CO2)(d) and x(CH3CH2OH)(c).Derived from the theory of association reaction,the mass action law-based model were established as x1(PC)=d3.89e(-2383.63/T-41.64) and x2(PC)=d3.17c0.36e(-1748.03/T-33.73) to correlate the experimental solubility in SC-CO2 with and without ethanol.The result shows there is a good agreement between experimental data and calculated data of solubility with absolute average relative deviation(AARD) of 4.31% and 3.78% respectively.