| Abstract: | In a prospective study we evaluated the work-place pollution by isoflurane and nitrous oxide during various anaesthetic procedures in animal surgery. The study was conducted during one working week at an University Animal Department. Trace concentrations of isoflurane and nitrous oxide were directly measured every minute in the breathing zone by means of a photoacoustic infrared spectrometer in two different operating rooms (OR) with an air turnover of 17 changes per hour. In one OR the 8-hour time-weighted average (mean +/- SEM) was calculated to be 12.3 +/- 9.9 ppm nitrous oxide and 1.9 +/- 2.5 ppm isoflurane. The other OR, where only isoflurane was used, was contaminated with 5.3 +/- 8.1 ppm isoflurane. In the first OR, the trace gas concentrations were low and comparable to values obtained under human anaesthesia in adults and children. The higher contamination in the second OR resulted from performing inhalational anaesthesia with an open mask system in birds and small animals. Although the mean values were below the recommended occupational exposure standards, some high peak values (> 300 ppm isoflurane) violated these threshold limits. We recommend the use of a local scavenging device, if other alternatives such as total intravenous anaesthesia are not possible. |
