| 阿司匹林-维生素E酯的合成 |
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| 引用本文： | 杜伯,周洪柱. 阿司匹林-维生素E酯的合成[J]. 精细与专用化学品, 2006, 14(8): 20-22 |
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| 作者姓名： | 杜伯 周洪柱 |
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| 作者单位： | 大庆华科股份有限公司,黑龙江,大庆,163714;大庆华科股份有限公司,黑龙江,大庆,163714 |
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| 摘 要： | 以3种不同的路径分别合成了阿司匹林-维生素E酯的中间体,并通过红外光谱、高效液相色谱、核磁共振等手段对产物的结构进行了表征,证明所得均为目标产物。通过比较,确定以酰氯为酰化剂的合成方法产率较高,成本低,适合工业化生产。
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| 关 键 词： | 阿司匹林 维生素E 酰氯 二环己基脲 |
| 修稿时间： | 2006-02-17 |
Synthesis of Aspirin-tocopherol Ester |
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| DU Bo,ZHOU Hong-zhu. Synthesis of Aspirin-tocopherol Ester[J]. Fine and Specialty Chemicals, 2006, 14(8): 20-22 |
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| Authors: | DU Bo ZHOU Hong-zhu |
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| Abstract: | The intermediates of aspirin-tocopherol ester are synthesized by three routes,and the structure of products are characterized through infra-red spectrum,high efficiency liquid chromatography,nuclear magnetic resonance etc.,namely they are the objective products.Compared the methods,it is found that the routes using acyl chloride as acylating agent was the best one,which having high yield,low cost,and fitting industrial production. |
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| Keywords: | aspirin tocopherol acyl chloride dicyclohexylurea |
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