| 金属硫蛋白对胸腺嘧啶的辐射保护作用 |
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| 引用本文： | 方兴旺 吴季兰. 金属硫蛋白对胸腺嘧啶的辐射保护作用[J]. 辐射研究与辐射工艺学报, 1994, 12(1): 1-6 |
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| 作者姓名： | 方兴旺 吴季兰 |
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| 作者单位： | 北京大学技术物理系 |
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| 摘 要： | 用竞争动力学方法测定了金属硫蛋白清ＯＨ自由基的速率常数，研究了在Ｎ２Ｏ饱和的水溶液中金属硫蛋白对胸腺嘧啶的辐射保护作用。结果表明金属硫蛋白能有效地清除ＯＨ，对胸腺嘧啶有良好的保护作用。对胸腺嘧啶的氧饱和甲酸钠水溶液γ辐解产物分析表明，Ｏ＾－２和Ｈ２Ｏ２不会直接造成胸腺嘧啶的损伤。
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| 关 键 词： | 金属硫蛋白 胸腺嘧啶 放射保护作用 |
RADIOPROTECTIVE EFFECT OF METALLOTHIONEIN ON THYMINE |
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| Fang Xingwang, Wu Jilan, Wei Genshuan. RADIOPROTECTIVE EFFECT OF METALLOTHIONEIN ON THYMINE[J]. Journal of Radiation Research and Radiation Processing, 1994, 12(1): 1-6 |
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| Authors: | Fang Xingwang Wu Jilan Wei Genshuan |
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| Abstract: | The reaction rate Of metallothionein (MT) with hydroxyl radicalwas. determined to be ca. 1012mol-1.L.s-1 by studying the kinetic competition OfMT With ferrocyanide for OH which was generated in situ by irradiation. Radioprotective effect of MT on thyinine was studied in N2O--saturated phbsphate buffer solutions at pH 7. 0.Both isoforms of rabbit MT can protect thymine against radiation damage effectively, and their effectiveness is in the order of ZnMT--1 >ZnMT--2> (Cd,Zn) MT--1 > (Cd, Zn)MT--2. However,the dose reducing factor wasless than expected. Which was possibly due to the secondary reactions of RS withthymine or T(OH) radicals With MT. Radiation effect on thymine in O,--saturated0. 1 mol'L-l HCOONa:Sblution wad also studied, and the results showed that O2and H2O2 didn't cause direct damage to thymine. |
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| Keywords: | Metallothionein Thymine Radioprotection Kinetic analysis |
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