| 抗氧化剂α-硫辛酸的生物合成研究进展 |
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| 引用本文： | 阮丽娟,胡忠策,郑裕国. 抗氧化剂α-硫辛酸的生物合成研究进展[J]. 精细与专用化学品, 2012, 20(7): 49-53 |
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| 作者姓名： | 阮丽娟 胡忠策 郑裕国 |
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| 作者单位： | 浙江工业大学生物工程研究所,浙江杭州,310014 |
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| 摘 要： | α-硫辛酸及其还原态二氢硫辛酸具有极强的抗氧化性,可改善葡萄糖代谢,减弱氧化应激,对糖尿病性白内障、糖尿病多发性神经病及心血管损伤等糖尿病并发症具有较好的预防和治疗作用。概述了α-硫辛酸的作用机制、生物合成途径及应用,重点综述了具有良好应用前景的生物法生产α-硫辛酸工艺。
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| 关 键 词： | 抗氧化 α-硫辛酸 生物合成 研究进展 |
Research advances in biosynthesis of.alpha-lipoic acid for antioxidant |
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| RUAN Li-juan,HU Zhong-ce,ZHENG Yu-guo. Research advances in biosynthesis of.alpha-lipoic acid for antioxidant[J]. Fine and Specialty Chemicals, 2012, 20(7): 49-53 |
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| Authors: | RUAN Li-juan HU Zhong-ce ZHENG Yu-guo |
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| Affiliation: | (Institute of Bioengineering, Zh@ang University o{ Technology, Hangzhou ：310014, China) |
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| Abstract: | Alpha-lipoic acid and its reduced dihydrolipoic acid have strong antioxidative activity, they could improve glucose metabolism, diminish oxidative stress, and could prevent and treat diabetic cataract, diabetic polyneuropathy, cardiovascular damage and other complications of diabetes. α-Lipoic acid＇s mechanism of α- tion, biosynthetic pathway of α-lipoic acid, and its application, especially the biological production of α-lipoic acid which has broad prospects for application development were reviewed in this paper. |
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| Keywords: | antioxidative α- lipoic acid biosynthesis research advances |
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