The role of N-type Ca2+ channels in regulating excitability of guinea-pig sympathetic neurones |
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Authors: | DR Ireland PJ Davies EM McLachlan |
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Affiliation: | Department of Neurosciences, Ospedale Molinette, Turin, Italy. |
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Abstract: | Recent evidence suggests that central pain, i.e., pain due to central nervous system damage, may be due to a deranged neurotransmission between the sensory thalamus and sensory cortical areas. Central pain can be controlled either by opposing glutamate neurotransmission or potentiating GABAergic transmission. It is speculated that a relative hypofunction of the GABAergic inhibition both at thalamic and cortical levels leads to a sectorial excitatory hypertonus in those same areas. A blend of the two should mark each patient. A pharmacological dissection approach is provided that should optimize the treatment, up to now globally poor, of central pain. |
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