| Chemical component analysis of volatile oil in drug pair Herba Ephedrae-Ramulus Cinnamomi by GC-MS and CRM |
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| 作者姓名： | 陈勇 李晓如 赵君 周涛 邹桥 |
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| 作者单位： | The Second Xiangya Hospital Central South University，School of Chemistry and Chemical Engineering Central South University，School of Chemistry and Chemical Engineering Central South University，School of Chemistry and Chemical Engineering Central South University，School of Chemistry and Chemical Engineering Central South University，Changsha 410011 China，Changsha 410083 China，Changsha 410083 China，Changsha 410083 China，Changsha 410083 China |
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| 摘 要： | Active volatile components in drug pair(DP)Herba Ephedrae-Ramulus Cinnamomi(HE-RC),single drug HE and RC were analyzed by gas chromatography/mass spectrometry(GC/MS),chemometric resolution method(CRM)and overall volume integration.By means of CRM,the two-dimensional data obtained from GC-MS instruments were resolved into a pure chromatogram and a mass spectrum of each chemical compound.In total,97,62,and 78 volatile chemical components in volatile oil of HE,RC,and DP HE-RC,were respectively determined qualitatively and quantitatively,accounting for 90.08%,91.62%,and 89.76% total contents of volatile oil of HE,RC,and DP HE-RC respectively.It is further demonstrated that the numbers of volatile components of DP HE-RC are almost the sum of those of two single drugs,but some relative contents of them are changed.Some new components,such as 1,6-dimethylhepta-1,3,5-triene,tetracyclo4.2.1.1(2,5).0(9,10)]deca-3,7-diene,globulol and(E,E)-6,10,14-trimethyl-5,9,13-pentadecatrien-2-one are found in DP HE-RC because of chemical reactions and physical changes during decoction.
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| 关 键 词： | 药物配对 化学分析 挥发油 分辨能力 |
| 收稿时间： | 24 December 2006 |
| 修稿时间： | 2006-12-242007-03-28 |
Chemical component analysis of volatile oil in drug pair Herba Ephedrae-Ramulus Cinnamomi by GC-MS and CRM |
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| Chen Yong , Li Xiao-ru , Zhao Jun , Zhou Tao and Zou Qiao.Chemical component analysis of volatile oil in drug pair Herba Ephedrae-Ramulus Cinnamomi by GC-MS and CRM[J].Journal of Central South University of Technology,2007,14(4):509-513. |
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| Authors: | Chen Yong Li Xiao-ru Zhao Jun Zhou Tao and Zou Qiao |
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| Affiliation: | 1. The Second Xiangya Hospital, Central South University, Changsha 410011, China; 2. School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China |
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| Abstract: | Active volatile components in drug pair(DP)Herba Ephedrae-Ramulus Cinnamomi(HE-RC),single drug HE and RC were analyzed by gas chromatography/mass spectrometry(GC/MS),chemometric resolution method(CRM)and overall volume integration.By means of CRM,the two-dimensional data obtained from GC-MS instruments were resolved into a pure chromatogram and a mass spectrum of each chemical compound.In total,97,62,and 78 volatile chemical components in volatile oil of HE,RC,and DP HE-RC,were respectively determined qualitatively and quantitatively,accounting for 90.08%,91.62%,and 89.76% total contents of volatile oil of HE,RC,and DP HE-RC respectively.It is further demonstrated that the numbers of volatile components of DP HE-RC are almost the sum of those of two single drugs,but some relative contents of them are changed.Some new components,such as 1,6-dimethylhepta-1,3,5-triene,tetracyclo4.2.1.1(2,5).0(9,10)]deca-3,7-diene,globulol and(E,E)-6,10,14-trimethyl-5,9,13-pentadecatrien-2-one are found in DP HE-RC because of chemical reactions and physical changes during decoction. |
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| Keywords: | drug pair (DP) Herba Ephedrae-Ramulus Cinnamomi volatile oil gas chromatography/mass spectrometry (GC-MS) chemometric resolution method (CRM) |
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