Abstract: | To measure tinnitus induced by sodium salicylate injections, 84 rats were used in a conditioned suppression paradigm. In Exp 1, Ss were trained with a conditioned stimulus/stimuli (CS) consisting of the offset of a continuous background noise. One group began salicylate injections before Pavlovian training, a 2nd group started injections after training, and a control group received daily saline injections. Resistance to extinction was profound when injections started before training but minimal when initiated after training, suggesting that salicylate-induced effects acquired differential conditioned value. In Exp 2, salicylate treatments were mimicked by substituting a 7 kHz tone in place of respective injections, resulting in effects equivalent to salicylate-induced behavior. A 3rd experiment included a 3 kHz CS, and again replicated the salicylate findings. In Exp 4, we decreased the motivational level, and the sequential relation between salicylate-induced effects and suppression training was retained. Findings support the demonstration of phantom auditory sensations in animals. (PsycINFO Database Record (c) 2011 APA, all rights reserved) |