| 5-甲基-4-乙酰基-1-对氯苄基-1,2,3-三唑的合成研究 |
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| 引用本文： | 徐雪梅,罗再刚,何快,张明阳.5-甲基-4-乙酰基-1-对氯苄基-1,2,3-三唑的合成研究[J].精细化工中间体,2012,42(4):42-44. |
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| 作者姓名： | 徐雪梅 罗再刚 何快 张明阳 |
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| 作者单位： | 安徽理工大学 化学工程学院,安徽 淮南,232001 |
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| 基金项目： | 国家自然科学基金青年科学基金(21102003);安徽理工大学人才引进启动基金;安徽理工大学青年教师科学研究基金 |
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| 摘 要： | 以对氯苄基叠氮和乙酰丙酮为原料合成5-甲基-4-乙酰基-1-对氯苄基-1,2,3-三唑,考察了催化剂类型、溶剂、配比对反应的影响,并确定了优化的工艺条件:无水碳酸钾为催化剂,乙腈和乙醇等体积混合为反应溶剂,n(对氯苄基叠氮)∶n(乙酰丙酮)=1∶1.2,反应时间2 h。产品收率达94%,目标化合物的结构经1H NMR和IR确证。
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| 关 键 词： | 对氯苄基叠氮 1 2 3-三唑 合成 |
Synthesis of 1-(4-Chlorobenzyl)-4-acetyl-5-methyl-1,2,3-triazole |
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| XU Xue-mei
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LUO Zai-gang
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HE Kuai
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ZHANG Ming-yang.Synthesis of 1-(4-Chlorobenzyl)-4-acetyl-5-methyl-1,2,3-triazole[J].Fine Chemical Intermediates,2012,42(4):42-44. |
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| Authors: | XU Xue-mei LUO Zai-gang HE Kuai ZHANG Ming-yang |
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| Affiliation: | (College of Chemical Engineering,AnHui University of Science & Technology,Huainan 232001,China) |
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| Abstract: | 1-(4-Chlorobenzyl)-4-acetyl-5-methyl-1,2,3-triazole was synthesized from 1-(azidomethyl)-4-chlorobenzene and acetylacetone.Best results with 94% yield were obtained under conditions of catalyst of anhydrous potassium carbonate,reaction dissolvent of acetonitrile and ethanol(1∶1),molar ratio of 1-(azidomethyl)-4-chlorobenzene to acetylacetone of 1 to 1.2 and reaction time of 2 h.The structure of the title compound was confirmed by 1H NMR and IR. |
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| Keywords: | 1-(azidomethyl)-4-chlorobenzene 1 2 3-triazole synthesis |
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